Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.

Upadhyay, Anup K; Judge, Russell A; Li, Leiming; Pithawalla, Ron; Simanis, Justin; Bodelle, Pierre M; Marin, Violeta L; Henry, Rodger F; Petros, Andrew M; Sun, Chaohong

Upadhyay, Anup K; Judge, Russell A; Li, Leiming; Pithawalla, Ron; Simanis, Justin; Bodelle, Pierre M; Marin, Violeta L; Henry, Rodger F; Petros, Andrew M; Sun, Chaohong.

Affiliation

Upadhyay AK; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA. Electronic address: anup.upadhyay@abbvie.com.
Judge RA; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Li L; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Pithawalla R; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Simanis J; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Bodelle PM; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Marin VL; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Henry RF; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Petros AM; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Sun C; AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.

Bioorg Med Chem Lett ; 28(10): 1708-1713, 2018 06 01.

Article de En | MEDLINE | ID: mdl-29691138

Sujet(s)
Mots clés

2D-NMR based fragment screening; Fragment based drug discovery; KDM4A tandem TUDOR domain

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Jumonji Domain-Containing Histone Demethylases Limites: Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2018 Type de document: Article

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