Synthesis and Guest Recognition of Switchable Pt-Salphen Based Molecular Tweezers.
Molecules
; 23(5)2018 04 24.
Article
de En
| MEDLINE
| ID: mdl-29695059
ABSTRACT
Molecular tweezers are artificial receptors that have an open cavity generated by two recognition units pre-organized by a spacer. Switchable molecular tweezers, using a stimuli-responsive spacer, are particularly appealing as prototypes of the molecular machines that combine mechanical motion and allosteric recognition properties. In this present study, the synthesis of switchable molecular tweezers composed of a central terpyridine unit substituted in 4,4â³ positions by two Pt(II)-salphen complexes is reported. The terpyridine ligand can be reversibly converted upon Zn(II) coordination from a free 'U'-shaped closed form to a coordinated 'W' open form. This new substitution pattern enables a reverse control of the mechanical motion compared to the previously reported 6,6â³ substituted terpyridine-based tweezers. Guest binding studies with aromatic guests showed an intercalation of coronene in the cavity created by the Pt-salphen moieties in the closed conformation. The formation of 11 host-guest complex was investigated by a combination of NMR studies and DFT calculations.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Phénylènediamines
/
Modèles moléculaires
/
Conformation moléculaire
Langue:
En
Journal:
Molecules
Sujet du journal:
BIOLOGIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
France