Oncogenic Mutants of MEK1: A Trilogy Unfolds.
Cancer Discov
; 8(5): 534-536, 2018 05.
Article
de En
| MEDLINE
| ID: mdl-29716939
ABSTRACT
It has generally been assumed that MEK mutants function similarly to one another and respond in the same manner to targeted drugs. Gao and colleagues challenge this assumption and report that MEK1 mutants fall into three unique phenotypic classes with respect to RAF dependency. A new class of MEK1 mutants is shown here to be RAF-independent, resistant to allosteric MEK inhibitors, and yet sensitive to treatment with a new ATP-competitive MEK inhibitor. Cancer Discov; 8(5); 534-6. ©2018 AACRSee related article by Gao et al., p. 648.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Inhibiteurs de protéines kinases
Langue:
En
Journal:
Cancer Discov
Année:
2018
Type de document:
Article