Synthesis and kinetic evaluation of ethyl acrylate and vinyl sulfone derived inhibitors for human cysteine cathepsins.

Breuer, Christian; Lemke, Carina; Schmitz, Janina; Bartz, Ulrike; Gütschow, Michael

Breuer, Christian; Lemke, Carina; Schmitz, Janina; Bartz, Ulrike; Gütschow, Michael.

Affiliation

Breuer C; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany; Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, von-Liebig-Strasse 20, D-53359 Rheinbach, Germany.
Lemke C; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany.
Schmitz J; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany; Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, von-Liebig-Strasse 20, D-53359 Rheinbach, Germany.
Bartz U; Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, von-Liebig-Strasse 20, D-53359 Rheinbach, Germany.
Gütschow M; Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany. Electronic address: guetschow@uni-bonn.de.

Bioorg Med Chem Lett ; 28(11): 2008-2012, 2018 06 15.

Article de En | MEDLINE | ID: mdl-29748052

Sujet(s)
Mots clés

Cathepsins; Cysteine proteases; Horner-Wadsworth-Emmons olefination; Irreversible inhibition; Michael acceptors

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sulfones / Acrylates / Cathepsines / Antienzymes Limites: Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2018 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: Royaume-Uni

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