SULFATION PATHWAYS: Insights into steroid sulfation and desulfation pathways.
J Mol Endocrinol
; 61(2): T271-T283, 2018 08.
Article
de En
| MEDLINE
| ID: mdl-29764919
ABSTRACT
Sulfation and desulfation pathways represent highly dynamic ways of shuttling, repressing and re-activating steroid hormones, thus controlling their immense biological potency at the very heart of endocrinology. This theme currently experiences growing research interest from various sides, including, but not limited to, novel insights about phospho-adenosine-5'-phosphosulfate synthase and sulfotransferase function and regulation, novel analytics for steroid conjugate detection and quantification. Within this review, we will also define how sulfation pathways are ripe for drug development strategies, which have translational potential to treat a number of conditions, including chronic inflammatory diseases and steroid-dependent cancers.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Stéroïdes
/
Sulfates
Limites:
Animals
/
Humans
Langue:
En
Journal:
J Mol Endocrinol
Sujet du journal:
BIOLOGIA MOLECULAR
/
ENDOCRINOLOGIA
Année:
2018
Type de document:
Article