Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions.
Inflamm Res
; 67(8): 633-654, 2018 Aug.
Article
de En
| MEDLINE
| ID: mdl-29767332
ABSTRACT
INTRODUCTION:
Pain is an unpleasant sensation triggered by noxious stimulation. It is one of the most prevalent conditions, limiting productivity and diminishing quality of life. Non steroidal anti inflammatory drugs (NSAIDs) are widely used as pain relievers in present day practice as pain is mostly initiated due to inflammation. However, due to potentially serious side effects, long term use of these antihyperalgesic drugs raises concern. Therefore there is a demand to search novel medicines with least side effects. Herbal products have been used for centuries to reduce pain and inflammation, and phytochemicals are known to cause fewer side effects. However, identification of active phytochemicals of herbal medicines and clear understanding of the molecular mechanism of their action is needed for clinical acceptance. MATERIALS ANDMETHODS:
In this review, we have briefly discussed the cellular and molecular changes during hyperalgesia via inflammatory mediators and neuro-modulatory action involved therein. The review includes 54 recently reported phytochemicals with antihyperalgesic action, as per the literature available with PubMed, Google Scholar and Scopus.CONCLUSION:
Compounds of high interest as potential antihyperalgesic agents are curcumin, resveratrol, capsaicin, quercetin, eugenol, naringenin and epigallocatechin gallate (EGCG). Current knowledge about molecular targets of pain and their regulation by these phytochemicals is elaborated and the scope of further research is discussed.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Douleur
/
Anti-inflammatoires non stéroïdiens
/
Composés phytochimiques
/
Analgésiques
Aspects:
Patient_preference
Limites:
Animals
/
Humans
Langue:
En
Journal:
Inflamm Res
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
Inde