Geographic range expansion of tetrodotoxin in amphibians - First record in Atelopus hoogmoedi from the Guiana Shield.
Toxicon
; 150: 175-179, 2018 Aug.
Article
de En
| MEDLINE
| ID: mdl-29782950
ABSTRACT
For the first time, alcohol extracts of Atelopus hoogmoedi from the Guiana Shield in Suriname and Guyana were analyzed for the presence of tetrodotoxin (TTX) and of its analogues by high resolution hydrophilic interaction liquid chromatography/mass spectrometry. One specimen from Suriname was found to contain TTX and 4-epiTTX. Using a monoclonal antibody-based immunohistochemical staining technique, TTX was localized mainly in the granular glands and epithelium of the skin, but not in internal organs except liver showing weak TTX-positive reaction. In two specimens collected in Guyana, none of the toxins were detected.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tétrodotoxine
/
Bufonidae
Limites:
Animals
Pays/Région comme sujet:
America do sul
/
Caribe ingles
/
Guyana
Langue:
En
Journal:
Toxicon
Année:
2018
Type de document:
Article