Auditory steady state response deficits are associated with symptom severity and poor functioning in patients with psychotic disorder.
Schizophr Res
; 201: 278-286, 2018 11.
Article
de En
| MEDLINE
| ID: mdl-29807805
ABSTRACT
OBJECTIVES:
Gamma oscillation is important for cortico-cortical coordination and the integration of information across neural networks. The 40â¯Hz auditory steady-state response (ASSR), which reflects neural synchrony in the gamma band (30-100â¯Hz), is abnormal in patients with schizophrenia (SZ). The present study used the ASSR at multiple frequencies to examine (1) gamma dysfunction in patients with SZ, schizoaffective (SA), and bipolar disorder (BD) compared with controls, (2) the relationship between ASSR measures and clinical symptom severity, and (3) the relationship between ASSR measures and real-life community functioning.METHODS:
EEG was recorded from 75 controls, 52 SZ, 55 SA, and 89 BD patients during 20-30-40-Hz binaural click trains. ANCOVA was used to compare ASSR measures between groups controlling for age, sex, and education. Associations between ASSR measures, symptom severity, and community functioning were examined using linear regression and Pearson partial correlations.RESULTS:
ASSR deficits at gamma frequency were observed in all patient groups. SA patients showed additional specific deficit in the 20â¯Hz ASSR. Severity of manic, depressive, and anxiety symptoms mediated ASSR deficits. Severity of hallucinatory symptom and community functioning, particularly independent living/meaningful activity, were significantly and independently associated with the 40â¯Hz ASSR.CONCLUSIONS:
SZ, SA and BD patients are likely to share the same abnormalities in neural processes that generate gamma oscillations. 40â¯Hz ASSR are associated with community functioning across patients and may serve as a biomarker for predicting functional outcome.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Troubles psychotiques
/
Schizophrénie
/
Perception auditive
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Trouble bipolaire
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Encéphale
/
Rythme gamma
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Schizophr Res
Sujet du journal:
PSIQUIATRIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique