Active Sampling State Dynamically Enhances Olfactory Bulb Odor Representation.
Neuron
; 98(6): 1214-1228.e5, 2018 06 27.
Article
de En
| MEDLINE
| ID: mdl-29861286
ABSTRACT
The olfactory bulb (OB) is the first site of synaptic odor information processing, yet a wealth of contextual and learned information has been described in its activity. To investigate the mechanistic basis of contextual modulation, we use whole-cell recordings to measure odor responses across rapid learning episodes in identified mitral/tufted cells (MTCs). Across these learning episodes, diverse response changes occur already during the first sniff cycle. Motivated mice develop active sniffing strategies across learning that robustly correspond to the odor response changes, resulting in enhanced odor representation. Evoking fast sniffing in different behavioral states demonstrates that response changes during active sampling exceed those predicted from feedforward input alone. Finally, response changes are highly correlated in tufted cells, but not mitral cells, indicating there are cell-type-specific effects on odor representation during active sampling. Altogether, we show that active sampling is strongly associated with enhanced OB responsiveness on rapid timescales.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Bulbe olfactif
/
Comportement animal
/
Apprentissage discriminatif
/
Odorisants
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Neuron
Sujet du journal:
NEUROLOGIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
Royaume-Uni