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Isoflavones enhance pharmacokinetic exposure of active lovastatin acid via the upregulation of carboxylesterase in high-fat diet mice after oral administration of Xuezhikang capsules.
Feng, Dong; Ge, Chun; Tan, Zhao-Yi; Sun, Jian-Guo; Xie, Yuan; Yao, Lan; Yan, Cai-Xia; Aa, Ji-Ye; Wang, Guang-Ji.
Affiliation
  • Feng D; Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Ge C; Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210029, China.
  • Tan ZY; School of Basic Medicine & Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
  • Sun JG; Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Xie Y; Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Yao L; Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Yan CX; Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Aa JY; Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Wang GJ; Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. jiyea@cpu.edu.cn.
Acta Pharmacol Sin ; 39(11): 1804-1815, 2018 Nov.
Article de En | MEDLINE | ID: mdl-29921884
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Médicaments issus de plantes chinoises / Lovastatine / Hyperlipidémies / Isoflavones Limites: Animals / Humans / Male Langue: En Journal: Acta Pharmacol Sin Sujet du journal: FARMACOLOGIA Année: 2018 Type de document: Article Pays d'affiliation: Chine
Texte intégral
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Médicaments issus de plantes chinoises / Lovastatine / Hyperlipidémies / Isoflavones Limites: Animals / Humans / Male Langue: En Journal: Acta Pharmacol Sin Sujet du journal: FARMACOLOGIA Année: 2018 Type de document: Article Pays d'affiliation: Chine