Beneficial and adverse effects of antipsychotic medication on cognitive flexibility are related to COMT genotype in first episode psychosis.
Schizophr Res
; 202: 212-216, 2018 12.
Article
de En
| MEDLINE
| ID: mdl-29941295
ABSTRACT
This study evaluated the ability to flexibly shift cognitive set and to consistently maintain a new response preference using the Penn Conditional Exclusion Test (PCET). The relationship of performance errors with catechol-O-methyltransferase (COMT) rs4680 (Val158Met) genotype (Met carriers vs. Val homozygotes) on test performance before and after antipsychotic treatment in 32 first episode psychosis (FEP) patients was examined. After treatment, patients demonstrated a mixture of beneficial and adverse cognitive outcomes that varied in relation to COMT genotype. Met carriers showed decreased perseverative and regressive errors, reflecting improved cognitive flexibility and enhanced stability of behavioral preferences, respectively. In contrast, Val homozygotes exhibited an increase in regressive errors after treatment. These findings suggest that Val homozygotes may be vulnerable to adverse effects of antipsychotic medication on cognitive processes that maintain consistent adaptive response preferences, an ability linked to the striatum in rodent models.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Troubles psychotiques
/
Neuroleptiques
/
Catechol O-methyltransferase
/
Fonction exécutive
Type d'étude:
Prognostic_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Schizophr Res
Sujet du journal:
PSIQUIATRIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique