Glucose-Responsive Peptide Coacervates with High Encapsulation Efficiency for Controlled Release of Insulin.
Bioconjug Chem
; 29(7): 2176-2180, 2018 07 18.
Article
de En
| MEDLINE
| ID: mdl-29944344
ABSTRACT
A new glucose-responsive insulin delivery system is fabricated using biomimetic peptide coacervates derived from the Humboldt squid (Dosidicus Gigas) beak. Both insulin and glucose oxidase are coencapsulated within coacervate microdroplets. The glucose oxidase quickly responds to increasing glucose levels to generate a local acidic environment, thereby rapidly triggering the dissociation of pH-sensitive coacervates to release the insulin cargo. The rate of insulin release is dependent on the glucose level, increases under hyperglycemic conditions, and decreases under normoglycemic conditions. This glucose responsiveness mimics pancreatic ß-cell function by releasing insulin according to glucose levels.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Peptides
/
Capsules
/
Systèmes de délivrance de médicaments
/
Insuline
Limites:
Animals
/
Humans
Langue:
En
Journal:
Bioconjug Chem
Sujet du journal:
BIOQUIMICA
Année:
2018
Type de document:
Article