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Leptin and its receptor: can they help to differentiate chromophobe renal cell carcinoma from renal oncocytoma?
Ng, K L; Del Vecchio, S J; Samaratunga, H; Morais, C; Rajandram, R; Vesey, D A; Wood, S T; Gobe, G C.
Affiliation
  • Ng KL; Department of Urology, Princess Alexandra Hospital, Woolloongabba, Brisbane, Qld, Australia; Centre for Kidney Disease Research, Faculty of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Qld, Australia; Department of Surgery, Faculty of Medicine, Unive
  • Del Vecchio SJ; Centre for Kidney Disease Research, Faculty of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Qld, Australia.
  • Samaratunga H; Aquesta Pathology, Toowong, Qld, Australia.
  • Morais C; Centre for Kidney Disease Research, Faculty of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Qld, Australia.
  • Rajandram R; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Vesey DA; Centre for Kidney Disease Research, Faculty of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Qld, Australia.
  • Wood ST; Department of Urology, Princess Alexandra Hospital, Woolloongabba, Brisbane, Qld, Australia; Centre for Kidney Disease Research, Faculty of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Qld, Australia.
  • Gobe GC; Centre for Kidney Disease Research, Faculty of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Qld, Australia; NHMRC Centre of Research Excellence, Centre for Chronic Disease, University of Queensland, Herston, Brisbane, Qld, Australia. Electronic addre
Pathology ; 50(5): 504-510, 2018 Aug.
Article de En | MEDLINE | ID: mdl-29970253
ABSTRACT
One of the challenges in differentiating chromophobe renal cell carcinoma (chRCC) from benign renal oncocytoma (RO) is overlapping morphology between the two subtypes. The aim of this study was to investigate the usefulness of expression of leptin (Ob) and its receptor (ObR) in discriminating chRCC from RO. Sections from paraffin-embedded, formalin-fixed tumour nephrectomy specimens of 45 patients, made up of 30 chRCC (15 eosinophilic variant and 15 non-eosinophilic variant) and 15 RO, were used in this study. Samples (30) of clear cell RCC (ccRCC), the most common histological subtype, were used to verify staining patterns found by others in our cohort of Australasian patients. Matched morphologically normal non-cancer kidney tissues were included for each specimen. Sections were batch-immunostained using antibodies against Ob and ObR. Stained sections were digitally scanned using Aperio ImageScope, and the expression pattern of Ob and ObR was studied. In this cohort, male to female ratio was 21; median age was 64 (45-88 years); and median tumour size was 3.8 cm (range 1.2-18 cm). There were 47 (62.7%) T1, seven T2, 20 T3 and one T4 stage RCC. Two patients with ccRCC presented with metastases. Nuclear expression of Ob was significantly higher in RO compared with chRCC. The increased nuclear expression of Ob in RO compared with chRCC may be a useful aid in the difficult histological differentiation of RO from chRCC, especially eosinophilic variants of chRCC.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Néphrocarcinome / Marqueurs biologiques tumoraux / Adénome oxyphile / Leptine / Tumeurs du rein Type d'étude: Diagnostic_studies Limites: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Langue: En Journal: Pathology Année: 2018 Type de document: Article

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Néphrocarcinome / Marqueurs biologiques tumoraux / Adénome oxyphile / Leptine / Tumeurs du rein Type d'étude: Diagnostic_studies Limites: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Langue: En Journal: Pathology Année: 2018 Type de document: Article