Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).

Ryder, Tim F; Calabrese, Matthew F; Walker, Gregory S; Cameron, Kimberly O; Reyes, Allan R; Borzilleri, Kris A; Delmore, Jake; Miller, Russell; Kurumbail, Ravi G; Ward, Jessica; Kung, Daniel W; Brown, Janice A; Edmonds, David J; Eng, Heather; Wolford, Angela C; Kalgutkar, Amit S

Ryder, Tim F; Calabrese, Matthew F; Walker, Gregory S; Cameron, Kimberly O; Reyes, Allan R; Borzilleri, Kris A; Delmore, Jake; Miller, Russell; Kurumbail, Ravi G; Ward, Jessica; Kung, Daniel W; Brown, Janice A; Edmonds, David J; Eng, Heather; Wolford, Angela C; Kalgutkar, Amit S.

Affiliation

Ryder TF; Medicine Design , Pfizer Worldwide Research & Development , Groton , Connecticut 06340 , United States.
Calabrese MF; Medicine Design , Pfizer Worldwide Research & Development , Groton , Connecticut 06340 , United States.
Walker GS; Medicine Design , Pfizer Worldwide Research & Development , Groton , Connecticut 06340 , United States.
Borzilleri KA; Medicine Design , Pfizer Worldwide Research & Development , Groton , Connecticut 06340 , United States.
Kurumbail RG; Medicine Design , Pfizer Worldwide Research & Development , Groton , Connecticut 06340 , United States.
Kung DW; Medicine Design , Pfizer Worldwide Research & Development , Groton , Connecticut 06340 , United States.
Brown JA; Medicine Design , Pfizer Worldwide Research & Development , Groton , Connecticut 06340 , United States.
Eng H; Medicine Design , Pfizer Worldwide Research & Development , Groton , Connecticut 06340 , United States.
Wolford AC; Medicine Design , Pfizer Worldwide Research & Development , Groton , Connecticut 06340 , United States.

J Med Chem ; 61(16): 7273-7288, 2018 08 23.

Article de En | MEDLINE | ID: mdl-30036059

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Lipogenèse / AMP-Activated Protein Kinases / Indoles Limites: Animals / Humans / Male Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2018 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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