Leukoaraiosis severity and outcomes after mechanical thrombectomy with stent-retriever devices in acute ischemic stroke.
J Neurointerv Surg
; 11(2): 137-140, 2019 Feb.
Article
de En
| MEDLINE
| ID: mdl-30045947
ABSTRACT
BACKGROUND AND PURPOSE:
The aim of the study was to evaluate whether leukoaraiosis severity is associated with outcome in acute stroke patients undergoing mechanical thrombectomy with stent-retriever devices.METHODS:
In this retrospective multicenter study, we evaluated 251 acute stroke patients (pretreatment National Institutes of Health Stroke Scale score ≥8) treated with stent-retriever devices. Leukoaraiosis severity was graded as 0-2 (absent-to-moderate) versus 3-4 (severe) according to the van Swieten scale. The main clinical outcome was the proportion of good functional outcome, defined as a modified Rankin Scale of 0-2 at 90 days.RESULTS:
Significantly fewer patients in the severe LA group than in the absent-to-moderate LA group achieved a good functional outcome (18.4% vs 50.2%, P<0.001). In multivariable analysis, severe leukoaraiosis was a significant negative predictor of good functional outcome at 90 days (OR, 0.27; 95% CI 0.10-0.77; P=0.014).CONCLUSIONS:
The severity of leukoaraiosis is independently associated with 90-day functional outcome in acute stroke patients undergoing mechanical thrombectomy with stent-retriever devices.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Indice de gravité de la maladie
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Endoprothèses
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Encéphalopathie ischémique
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Accident vasculaire cérébral
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Leucoaraïose
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Thrombolyse mécanique
Type d'étude:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limites:
Aged
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Aged80
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Female
/
Humans
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Male
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Middle aged
Langue:
En
Journal:
J Neurointerv Surg
Année:
2019
Type de document:
Article
Pays d'affiliation:
Chine