Potential Pathways Associated With Exaggerated T Follicular Helper Response in Human Autoimmune Diseases.
Front Immunol
; 9: 1630, 2018.
Article
de En
| MEDLINE
| ID: mdl-30061896
ABSTRACT
Convincing lines of evidence in both mice and humans show that exaggerated T follicular helper (Tfh) responses is pathogenic in autoimmune diseases. However, the cause of exaggerated Tfh response in humans is still much less clear than in mouse models where genetic factors can be manipulated for in vivo testing. Nonetheless, recent advances in our understanding on the mechanisms of human Tfh differentiation and identification of multiple risk loci in genome-wide association studies have revealed several pathways potentially associated with exaggerated Tfh response in human autoimmune diseases. In this review, we will first briefly summarize the differentiation mechanisms of Tfh cells in humans. We describe the features of "Tfh-like" cells recently identified in inflamed tissues of human autoimmune diseases. Then we will discuss how risk loci identified in GWAS are potentially involved in exaggerated Tfh response in human autoimmune diseases.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Type d'étude:
Prognostic_studies
/
Risk_factors_studies
Langue:
En
Journal:
Front Immunol
Année:
2018
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique
Pays de publication:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND