Treatment of bleeding episodes in haemophilia A complicated by a factor VIII inhibitor in patients receiving Emicizumab. Interim guidance from UKHCDO Inhibitor Working Party and Executive Committee.
Haemophilia
; 24(3): 344-347, 2018 May.
Article
de En
| MEDLINE
| ID: mdl-30070072
ABSTRACT
Emicizumab is a bispecific antibody that activates FX to FXa in the absence of FVIII. It has been shown to reduce bleeding episodes in people with haemophilia A complicated by a FVIII inhibitor. Despite the protection against bleeds, some breakthrough bleeds are inevitable and these may require additional haemostatic treatment. Emicizumab has been associated with severe adverse events when co-administered with activated prothrombin complex concentrate. To minimize the risk of adverse events, the UK Haemophilia Centre Doctors' Organisation issues the following updated interim guidance to its Inhibitor Guidelines for managing patients receiving Emicizumab based on the limit published information available in February 2018.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Facteur VIII
/
Recommandations comme sujet
/
Anticorps bispécifiques
/
Anticorps monoclonaux humanisés
/
Hémophilie A
/
Hémorragie
Type d'étude:
Guideline
Limites:
Humans
Langue:
En
Journal:
Haemophilia
Sujet du journal:
HEMATOLOGIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
Royaume-Uni