The predictor markers of ovarian response in poor responders under 40 years of age.

ABSTRACT

OBJECTIVE: To explore the ovarian reserve markers in predicting ovarian response and pregnancy rates in poor responder patients undergoing in vitro fertilization (IVF). MATERIAL AND METHODS: A total of 140 women < 40 years with poor ovarian response (POR), who underwent IVF were included in the study. The clinical findings compared with normal responder controls (n= 250). Regression analysis was used to search the correlation between the number of the total oocyte count retrieved and independent variables as age, FSH, LH, AMH, AFC, and E2 on the hCG day. RESULTS: AUC ROC curve were AMH 0.804, AFC 0.701, E2 on hCG day 0.786, FSH 0.705, LH 0.527, and E2 0.479, age 0.707, respectively. E2 levels on hCG day and AMH levels were independent markers of POR. None of the factors were predictor of pregnancy rate. CONCLUSION: The serum E2 levels on the hCG day and AMH levels predict ovarian response, but not pregnancy rates.