Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFß1 Axis.

Prete, Alessandro; Lo, Agnes S; Sadow, Peter M; Bhasin, Swati S; Antonello, Zeus A; Vodopivec, Danica M; Ullas, Soumya; Sims, Jennifer N; Clohessy, John; Dvorak, Ann M; Sciuto, Tracey; Bhasin, Manoj; Murphy-Ullrich, Joanne E; Lawler, Jack; Karumanchi, S Ananth; Nucera, Carmelo

Prete, Alessandro; Lo, Agnes S; Sadow, Peter M; Bhasin, Swati S; Antonello, Zeus A; Vodopivec, Danica M; Ullas, Soumya; Sims, Jennifer N; Clohessy, John; Dvorak, Ann M; Sciuto, Tracey; Bhasin, Manoj; Murphy-Ullrich, Joanne E; Lawler, Jack; Karumanchi, S Ananth; Nucera, Carmelo.

Affiliation

Prete A; Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Experimental Pathology, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Lo AS; Department of Pathology, Center for Vascular Biology Research (CVBR), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Sadow PM; Department of Medicine, Center for Vascular Biology Research (CVBR), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Bhasin SS; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Antonello ZA; Bioinformatic and Systems Biology Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Vodopivec DM; Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Experimental Pathology, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Ullas S; Department of Pathology, Center for Vascular Biology Research (CVBR), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Sims JN; Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Experimental Pathology, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Clohessy J; Department of Pathology, Center for Vascular Biology Research (CVBR), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Dvorak AM; Longwood Small Animal Imaging Facility (LSAIF), Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Sciuto T; Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Experimental Pathology, Cancer Research Institute (CRI), Cancer Center, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Bhasin M; Department of Pathology, Center for Vascular Biology Research (CVBR), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Murphy-Ullrich JE; Division of Cancer Genetics, Department of Medicine, Beth Israel Deaconess Medical School, Harvard Medical School, Boston, Massachusetts.
Lawler J; Department of Pathology, Center for Vascular Biology Research (CVBR), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Karumanchi SA; Department of Pathology, Center for Vascular Biology Research (CVBR), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Nucera C; Bioinformatic and Systems Biology Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Clin Cancer Res ; 24(23): 6078-6097, 2018 12 01.

Article de En | MEDLINE | ID: mdl-30076136

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs de la thyroïde / Résistance aux médicaments antinéoplasiques / Péricytes / Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines / Facteur de croissance transformant bêta-1 / Vémurafénib Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Clin Cancer Res Sujet du journal: NEOPLASIAS Année: 2018 Type de document: Article

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