Stability, Cellular Uptake, and in Vivo Tracking of Zwitterion Modified Graphene Oxide as a Drug Carrier.
Langmuir
; 35(5): 1495-1502, 2019 02 05.
Article
de En
| MEDLINE
| ID: mdl-30089359
ABSTRACT
In this paper, a novel kind of zwitterion modified graphene oxide (GO) for promoting stability and reducing aggregation of GO as a drug carrier was proposed and demonstrated. Specifically, the GO was functionalized with a kind of zwitterion based silane, 3-(dimethyl(3-(trimethoxysilyl)propyl)-ammonio)propane-1-sulfonate (SBS). After zwitterion modification, the SBS functionalized GO (GO-SB) shows significantly enhanced stability in both serum-free and serum-containing solution, especially after loading doxorubicin hydrochloride (DOX). According to drug release profiles, the drug-loaded GO-SB exhibits thermosensitive and sustained release behavior. Meanwhile, in vitro studies show that the DOX loaded GO-SB could be easily internalized by HepG2 cells and exhibit obvious cytotoxicity on the cells. And, in vivo studies demonstrate that the GO-SB drug carrier is capable of being taken by the larvae of zebrafish and can be eliminated from the body within several days.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Silanes
/
Vecteurs de médicaments
/
Doxorubicine
/
Graphite
/
Antinéoplasiques
Limites:
Animals
/
Humans
Langue:
En
Journal:
Langmuir
Sujet du journal:
QUIMICA
Année:
2019
Type de document:
Article