Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN&#8482;) mice dosed orally with fenclozic acid.

Akingbasote, James A; Foster, Alison J; Jones, Huw B; David, Rhiannon; Gooderham, Nigel J; Wilson, Ian D; Kenna, J Gerry

Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid.

Akingbasote, James A; Foster, Alison J; Jones, Huw B; David, Rhiannon; Gooderham, Nigel J; Wilson, Ian D; Kenna, J Gerry.

Affiliation

Akingbasote JA; MRC Centre for Drug Safety Science , University of Liverpool , Liverpool , L69 3GE , UK . Email: j.akingbasote@liverpool.ac.uk.
Foster AJ; Drug Safety and Metabolism , Unit 310 - Darwin Building , Cambridge Science Park , Milton Road , Cambridge , CB4 0WG , UK . Email: alison.foster2@astrazeneca.com ; Email: huwbjoneshb@gmail.com ; Email: Rhiannon.David@astrazeneca.com.
Jones HB; Drug Safety and Metabolism , Unit 310 - Darwin Building , Cambridge Science Park , Milton Road , Cambridge , CB4 0WG , UK . Email: alison.foster2@astrazeneca.com ; Email: huwbjoneshb@gmail.com ; Email: Rhiannon.David@astrazeneca.com.
David R; Drug Safety and Metabolism , Unit 310 - Darwin Building , Cambridge Science Park , Milton Road , Cambridge , CB4 0WG , UK . Email: alison.foster2@astrazeneca.com ; Email: huwbjoneshb@gmail.com ; Email: Rhiannon.David@astrazeneca.com.
Gooderham NJ; Section of Computational and Systems Medicine , Department of Surgery and Cancer Faculty of Medicine , Imperial College London , South Kensington Campus , London , SW7 2AZ UK . Email: n.gooderham@imperial.ac.uk ; Email: iwilson@imperial.ac.uk.
Wilson ID; Section of Computational and Systems Medicine , Department of Surgery and Cancer Faculty of Medicine , Imperial College London , South Kensington Campus , London , SW7 2AZ UK . Email: n.gooderham@imperial.ac.uk ; Email: iwilson@imperial.ac.uk.
Kenna JG; Drug Safety Consultant , Macclesfield , UK . Email: j.gerrykenna@gmail.com ; Tel: +44 (0)1625432113.

Toxicol Res (Camb) ; 6(1): 81-88, 2017 Jan 01.

Article de En | MEDLINE | ID: mdl-30090479

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Toxicol Res (Camb) Année: 2017 Type de document: Article Pays de publication: Royaume-Uni

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