γδ T cells modulate humoral immunity against Plasmodium berghei infection.
Immunology
; 155(4): 519-532, 2018 12.
Article
de En
| MEDLINE
| ID: mdl-30144035
It is unclear whether γδ T cells are involved in humoral immunity against Plasmodium infection. Here, we show that B-cell-immunodeficient mice and γδ T-cell-deficient mice were incapable of protecting against Plasmodium berghei XAT parasites. γδ T-cell-deficient mice developed reduced levels of antigen-specific antibodies during the late phase of infection. The numbers of follicular helper T cells and germinal centre B cells in γδ T-cell-deficient mice were lower than in wild-type mice during the late phase of infection. Expression profiling of humoral immunity-related cytokines in γδ T cells showed that interleukin-21 (IL-21) and interferon-γ (IFN-γ) are increased during the early stage of infection. Furthermore, blockade of IL-21 and IFN-γ signalling during the early stage of infection led to reduction in follicular helper T cells and germinal centre B cells. γδ T-cell production of IL-21 and IFN-γ is crucial for the development and maintenance of follicular helper T cells and germinal centre B cells during the late phase of infection. Our data suggest that γδ T cells modulate humoral immunity against Plasmodium infection.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plasmodium berghei
/
Interleukines
/
Interféron gamma
/
Récepteur lymphocytaire T antigène, gamma-delta
/
Lymphocytes T auxiliaires
/
Immunité humorale
/
Paludisme
Limites:
Animals
Langue:
En
Journal:
Immunology
Année:
2018
Type de document:
Article
Pays d'affiliation:
Japon
Pays de publication:
Royaume-Uni