Theta band network supporting human episodic memory is not activated in the seizure onset zone.
Neuroimage
; 183: 565-573, 2018 12.
Article
de En
| MEDLINE
| ID: mdl-30144571
ABSTRACT
Episodic memory, everyday memory for events, is frequently impaired in patients with epilepsy. We tested patients undergoing intracranial electroencephalography (intracranial EEG) monitoring for the treatment of medically-refractory epilepsy on a well-characterized paradigm that requires episodic memory. We report that an anatomically diffuse network characterized by theta-band (4-7â¯Hz) coherence is activated at the time of target selection in a task that requires episodic memory. This distinct network of oscillatory activity is absent when episodic memory is not required. Further, the theta band synchronous network was absent in electrodes within the patient's seizure onset zone (SOZ). Our data provide novel empirical evidence for a set of brain areas that supports episodic memory in humans, and it provides a pathophysiologic mechanism for the memory deficits observed in patients with epilepsy.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Crises épileptiques
/
Lobe temporal
/
Rythme thêta
/
Mémoire épisodique
/
Électrocorticographie
/
Réseau nerveux
Limites:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Neuroimage
Sujet du journal:
DIAGNOSTICO POR IMAGEM
Année:
2018
Type de document:
Article