Granulocyte-macrophage colony-stimulating factor as a mediator of autoimmunity in multiple sclerosis.
J Neuroimmunol
; 323: 1-9, 2018 10 15.
Article
de En
| MEDLINE
| ID: mdl-30196820
ABSTRACT
Autoreactive, myelin-specific, CD4+ T cells have a central role in multiple sclerosis (MS) pathogenesis; however the exact phenotype characteristics of these cells remain elusive. Recently, granulocyte-macrophage colony-stimulating factor (GM-CSF) expression has emerged as the main pathological signature of the encephalogenicity in both T and B cell compartment. In this review we have summarized the current data supporting GM-CSF relevance in MS pathophysiology, in the context of both immunomodulatory and neuroinflammatory processes; as well as the potential cellular sources of this stimulating factor, including different T and B cell subsets.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Auto-immunité
/
Facteur de stimulation des colonies de granulocytes et de macrophages
/
Sclérose en plaques
Type d'étude:
Clinical_trials
Limites:
Animals
/
Humans
Langue:
En
Journal:
J Neuroimmunol
Année:
2018
Type de document:
Article