[MOLECULAR AND CELLULAR MECHANISMS OF ANGIOGENESIS IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS].
Ross Fiziol Zh Im I M Sechenova
; 103(2): 121-37, 2017 Feb.
Article
de Ru
| MEDLINE
| ID: mdl-30199169
ABSTRACT
In normal conditions vascular system is in equilibrium, the processes of angiogenesis and vascular regression are precisely regulated. The mechanisms underlying the cardiovascular and cancer diseases are the insufficient or excessive angiogenesis, correspondingly. Understanding the mechanisms of angiogenesis is necessary for the development of new approaches to cure these diseases. The fundamental knowledge of the vascular growth and maturation mechanisms formed the basis for the strategy of «therapeutic angiogenesis¼, which is one of the rapidly developing technologies in regenerative medicine in the world. The strategy is based on the stimulation of blood vessel growth and remodeling in ischemic tissues via administration of recombinant angiogenic factors or genetic constructs for their expression. The same knowledge of the mechanisms of angiogenesis is necessary in the development of new drugs aimed at inhibiting the vascular growth in excessive or aberrant angiogenesis, which escapes the physiological control in various diseases. Herein we review the fundamental molecular and cellular mechanisms of regulation of blood vessel initiation, growth, and stabilization in normal and pathological conditions.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vaisseaux sanguins
/
Maladies cardiovasculaires
/
Néovascularisation physiologique
/
Cellules endothéliales
/
Tumeurs
/
Néovascularisation pathologique
Limites:
Animals
/
Humans
Langue:
Ru
Journal:
Ross Fiziol Zh Im I M Sechenova
Sujet du journal:
FISIOLOGIA
Année:
2017
Type de document:
Article