Neurometabolic indicators of mitochondrial dysfunction in repetitive mild traumatic brain injury.
Concussion
; 2(3): CNC48, 2017 Nov.
Article
de En
| MEDLINE
| ID: mdl-30202587
ABSTRACT
Mild traumatic brain injury (mTBI) is a significant national health concern and there is growing evidence that repetitive mTBI (rmTBI) can cause long-term change in brain structure and function. The mitochondrion has been suggested to be involved in the mechanism of TBI. There are noninvasive methods of determining mitochondrial dysfunction through biomarkers and spectroscopy. Mitochondrial dysfunction has been implicated in a variety of neurological consequences secondary to rmTBI through activation of caspases and calpains. The purpose of this review is to examine the mechanism of mitochondrial dysfunction in rmTBI and its downstream effects on neuronal cell death, axonal injury and blood-brain barrier compromise.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Concussion
Année:
2017
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique