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A hyperactive mutant of interferon-regulatory factor 4.
Kang, Chol Ho; Hartmann, Enno; Menke, Lisa; Staudenraus, Daniel; Abass, El-Fadil; Raifer, Hartmann; Porapu, Alekya; Camara, Bärbel; Brüstle, Anne; Pinkenburg, Olaf; Bieringer, Maria; Lohoff, Michael.
Affiliation
  • Kang CH; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
  • Hartmann E; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
  • Menke L; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
  • Staudenraus D; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
  • Abass EF; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
  • Raifer H; Flow Cytometry Core Facility BMFZ¸ Philipps University Marburg, Marburg, Germany.
  • Porapu A; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
  • Camara B; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
  • Brüstle A; Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
  • Pinkenburg O; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
  • Bieringer M; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
  • Lohoff M; Institute for Medical Microbiology Hospital Hygiene, Philipps University Marburg, Marburg, Germany.
Eur J Immunol ; 49(5): 812-815, 2019 05.
Article de En | MEDLINE | ID: mdl-30218581
ABSTRACT
We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon-regulatory factor) C-terminus creates hyperactive IRF4. When introduced into IRF4-deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2-linked IL-13 production were much less altered.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sous-populations de lymphocytes T / Facteurs de régulation d'interféron / Mutation Limites: Animals / Humans Langue: En Journal: Eur J Immunol Année: 2019 Type de document: Article Pays d'affiliation: Allemagne
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sous-populations de lymphocytes T / Facteurs de régulation d'interféron / Mutation Limites: Animals / Humans Langue: En Journal: Eur J Immunol Année: 2019 Type de document: Article Pays d'affiliation: Allemagne