Epidemiology of childhood-onset type 1 diabetes in Azerbaijan: Incidence, clinical features, biochemistry, and HLA-DRB1 status.
Diabetes Res Clin Pract
; 144: 252-259, 2018 Oct.
Article
de En
| MEDLINE
| ID: mdl-30218742
ABSTRACT
AIMS:
Determine the incidence and typology of diabetes in children in Azerbaijan.METHODS:
Clinical features, C-peptide, autoantibodies (glutamic acid decarboxylase 65 (GAD65) and islet antigen 2 (IA-2)), and HLA-DRB1 status were studied in 106 subjects <18â¯years of age who were recently diagnosed. 104 cases were consecutive. Incidence was determined for Baku and Absheron regions, where ascertainment is estimated to be essentially 100%.RESULTS:
104 of the 106 (98%) were diagnosed with type 1 diabetes, one with type 2 diabetes and one with atypical diabetes. Type 1 diabetes incidence in Baku City and Absheron was 7.05 per 100,000 population <15â¯years per year. Peak age of onset was 10â¯years. There was a slight male preponderance (malefemale 1.171), and no temporal association with seasons. Almost all type 1 diabetes subjects presented with classic symptoms including a high incidence (58%) of diabetic ketoacidosis. 86% presented with low C-peptide values (<0.13â¯nmol/L, <0.40â¯ng/mL) and 74% were positive for at least one type 1 diabetes-related autoantibody.CONCLUSIONS:
Azerbaijan has a moderate type 1 diabetes incidence and clinical, biochemical and genetic features similar to that in European populations.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Autoanticorps
/
Peptide C
/
Marqueurs biologiques
/
Diabète de type 1
/
Chaines HLA-DRB1
Type d'étude:
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limites:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Diabetes Res Clin Pract
Sujet du journal:
ENDOCRINOLOGIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
Azerbaïdjan