Anterior-posterior gradient of plasticity in primate prefrontal cortex.
Nat Commun
; 9(1): 3790, 2018 09 17.
Article
de En
| MEDLINE
| ID: mdl-30224705
ABSTRACT
The functional organization of the primate prefrontal cortex has been a matter of debate with some models speculating dorso-ventral and rostro-caudal specialization while others suggesting that information is represented dynamically by virtue of plasticity across the entire prefrontal cortex. To address functional properties and capacity for plasticity, we recorded from different prefrontal sub-regions and analyzed changes in responses following training in a spatial working memory task. This training induces more pronounced changes in anterior prefrontal regions, including increased firing rate during the delay period, selectivity, reliability, information for stimuli, representation of whether a test stimulus matched the remembered cue or not, and variability and correlation between neurons. Similar results are obtained for discrete subdivisions or when treating position along the anterior-posterior axis as a continuous variable. Our results reveal that anterior aspects of the lateral prefrontal cortex of non-human primates possess greater plasticity based on task demands.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cortex préfrontal
/
Mémoire à court terme
/
Plasticité neuronale
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Nat Commun
Sujet du journal:
BIOLOGIA
/
CIENCIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique