Activation of RAAS in a rat model of liver cirrhosis: no effect of losartan on renal sodium excretion.
BMC Nephrol
; 19(1): 238, 2018 09 19.
Article
de En
| MEDLINE
| ID: mdl-30231858
ABSTRACT
BACKGROUND:
Liver cirrhosis is characterized by avid sodium retention where the activation of the renin angiotensin aldosterone system (RAAS) is considered to be the hallmark of the sodium retaining mechanisms. The direct effect of angiotensin II (ANGII) on the AT-1 receptor in the proximal tubules is partly responsible for the sodium retention. The aim was to estimate the natriuretic and neurohumoral effects of an ANGII receptor antagonist (losartan) in the late phase of the disease in a rat model of liver cirrhosis.METHODS:
Bile duct ligated (BDL) and sham operated rats received 2 weeks of treatment with losartan 4 mg/kg/day or placebo, given by gastric gavage 5 weeks after surgery. Daily sodium and potassium intakes and renal excretions were measured.RESULTS:
The renal sodium excretion decreased in the BDL animals and this was not affected by losartan treatment. At baseline the plasma renin concentration (PRC) was similar in sham and BDL animals, but increased urinary excretion of ANGII and an increase P-Aldosterone was observed in the placebo treated BDL animals. The PRC was more than 150 times higher in the losartan treated BDL animals (p < 0.001) which indicated hemodynamic impairment.CONCLUSIONS:
Losartan 4 mg/kg/day did not increase renal sodium excretion in this model of liver cirrhosis, although the urinary ANGII excretion was increased. The BDL animals tolerated Losartan poorly, and the treatment induced a 150 times higher PRC.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Système rénine-angiotensine
/
Sodium
/
Losartan
/
Antagonistes du récepteur de type 1 de l'angiotensine-II
/
Modèles animaux de maladie humaine
/
Cirrhose du foie
Limites:
Animals
Langue:
En
Journal:
BMC Nephrol
Sujet du journal:
NEFROLOGIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
Danemark