Age-related nomograms of serum anti-Mullerian hormone levels in female monkeys: Comparison of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) monkeys.
Gen Comp Endocrinol
; 269: 171-176, 2018 12 01.
Article
de En
| MEDLINE
| ID: mdl-30243886
ABSTRACT
AMH is regarded as a promising predictor for ovarian reserve in humans and non-human primate, and widely used in human medicine to predict ovarian response to gonadotropin, menopause and premature ovarian failure. However, large data set on the range of AMH levels in nonhuman primates is still scarce, which limited its applications largely. In this study, age-related AMH nomograms of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) were produced and compared. 219 rhesus and 529 cynomolgus monkeys ranging from infancy to adult were included. In total, the mean serum AMH levels in cynomolgus monkeys were higher than that of rhesus monkeys (14.6⯱â¯5.3â¯ng/ml vs 9.5⯱â¯6.0â¯ng/ml, Pâ¯<â¯0.001). AMH was inversely correlated with age (râ¯=â¯-0.371, Pâ¯<â¯0.001) in rhesus, while the negative correlation did not reach statistical significance in cynomolgus monkeys (râ¯=â¯-0.044, Pâ¯=â¯0.156). The maximum mean AMH levels were attained at the subgroup of 4-11â¯yr and the lowest AMH levels were obtained at the subgroup of â§12â¯yr in both primates, corresponding to their fertility potential. In rhesus monkeys, from 1 to 11â¯years old, AMH level remained stable (1-3â¯yr ßâ¯=â¯2.784, Pâ¯=â¯0.340; 4-11â¯yr râ¯=â¯0.100, Pâ¯=â¯0.110) whereas from 12â¯yr onward, an inverse correlation between AMH and age (râ¯=â¯-0.450, Pâ¯=â¯0.02) was observed. Similarly, AMH appeared stable from 1 to 3â¯yr (ßâ¯=â¯-2.289, Pâ¯=â¯0.429) and showed an inverse correlation with age (râ¯=â¯-0.521, Pâ¯<â¯0.001) from 12â¯yr onward in cynomolgus monkeys, while a positive correlation was observed (râ¯=â¯0.156, Pâ¯=â¯0.001) from 4 to 11â¯yr. AMH levels were relatively stable across the menstrual cycle in both primates and no seasonal difference for AMH levels was observed in rhesus monkeys. Body mass index did not affect serum AMH levels in both primates. Our nomograms of serum AMH provide a reference guide on AMH longitudinal distribution by age for Macaca monkeys and might facilitate its applications.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vieillissement
/
Nomogrammes
/
Hormone antimullérienne
/
Macaca fascicularis
/
Macaca mulatta
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Female
/
Humans
Langue:
En
Journal:
Gen Comp Endocrinol
Année:
2018
Type de document:
Article
Pays d'affiliation:
Chine