Effects of mucus thickness and goblet cell hyperplasia on microdosimetric quantities characterizing the bronchial epithelium upon radon exposure.
Int J Radiat Biol
; 94(11): 967-974, 2018 11.
Article
de En
| MEDLINE
| ID: mdl-30265181
ABSTRACT
PURPOSE:
The most exposed tissue upon radon exposure is the bronchial epithelium where goblet cells serve as responsive and adaptable front-line defenders. They can rapidly produce a vast amount of mucus, and can change in number, in response to airway insults. The objective of the present study is to quantify the effects of mucus discharge and goblet cell hyperplasia on the microscopic dose consequences of macroscopic radon exposures.METHODS:
For this purpose, computational models of the bronchial epithelium and alpha-particle transport have been prepared and applied to quantify the hits received and doses absorbed by cell nuclei in case of different mucus thicknesses and goblet cell number. RESULTS ANDCONCLUSIONS:
Both mucus discharge and induction of goblet cell hyperplasia reduce radiation burden at the cellular level, and as such they both can be considered as radioadaptive responses to radon exposure. As compared to basal cell hyperplasia, goblet cell hyperplasia is more effective in reducing the microscopic dose consequences of a given macroscopic exposure. Such changes in exposure geometry highlight the need for improvements in the application of biokinetic and dosimetry models for incorporated radionuclides as well as the dose and dose rate effectiveness factor.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Bronches
/
Radon
/
Cellules caliciformes
/
Mucus
Type d'étude:
Prognostic_studies
Langue:
En
Journal:
Int J Radiat Biol
Sujet du journal:
RADIOLOGIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
Hongrie