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Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation.
Deshpande, Tanvi M; Pagare, Piyusha P; Ghatge, Mohini S; Chen, Qiukan; Musayev, Faik N; Venitz, Jurgen; Zhang, Yan; Abdulmalik, Osheiza; Safo, Martin K.
Affiliation
  • Deshpande TM; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23219, USA.
  • Pagare PP; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23219, USA.
  • Ghatge MS; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23219, USA.
  • Chen Q; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Musayev FN; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23219, USA.
  • Venitz J; Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23219, USA.
  • Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23219, USA.
  • Abdulmalik O; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Safo MK; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23219, USA.
Acta Crystallogr D Struct Biol ; 74(Pt 10): 956-964, 2018 Oct 01.
Article de En | MEDLINE | ID: mdl-30289405

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Benzaldéhydes / Hémoglobine S / Stabilité protéique Type d'étude: Guideline / Prognostic_studies Limites: Humans Langue: En Journal: Acta Crystallogr D Struct Biol Année: 2018 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Benzaldéhydes / Hémoglobine S / Stabilité protéique Type d'étude: Guideline / Prognostic_studies Limites: Humans Langue: En Journal: Acta Crystallogr D Struct Biol Année: 2018 Type de document: Article Pays d'affiliation: États-Unis d'Amérique