A Family Focused Intervention Influences Hippocampal-Prefrontal Connectivity Through Gains in Self-Regulation.
Child Dev
; 90(4): 1389-1401, 2019 07.
Article
de En
| MEDLINE
| ID: mdl-30295319
ABSTRACT
The stressors associated with poverty increase the risks for externalizing psychopathology; however, specific patterns of neurobiology and higher self-regulation may buffer against these effects. This study leveraged a randomized control trial, aimed at increasing self-regulation at ~11 years of age. As adults, these same individuals completed functional MRI scanning (Mage = 24.88 years; intervention n = 44; control n = 49). Functional connectivity between the hippocampus and ventromedial prefrontal cortex was examined in relation to the intervention, gains in self-regulation, and present-day externalizing symptoms. Increased connectivity between these brain areas was noted in the intervention group compared to controls. Furthermore, individual gains in self-regulation, instilled by the intervention, statistically explained this brain difference. These results begin to connect neurobiological and psychosocial markers of risk and resiliency.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Symptômes comportementaux
/
Comportement de l'enfant
/
Cortex préfrontal
/
Thérapie familiale
/
Connectome
/
Sang-froid
/
Hippocampe
Type d'étude:
Clinical_trials
Limites:
Adult
/
Child
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Child Dev
Année:
2019
Type de document:
Article