Saturated phospholipids are required for nano- to micron-size transformation of cholesterol-containing liposomes upon QS21 addition.
J Liposome Res
; 29(3): 247-250, 2019 Sep.
Article
de En
| MEDLINE
| ID: mdl-30350748
ABSTRACT
Liposomes containing cholesterol and monophosphoryl lipid A (such as ALFQ and AS01B) are vaccine adjuvants. During construction of the formulations, addition of QS21 to nano-size (50-100 nm) liposomes resulted in extremely large (up to â¼30 µm) liposomes in ALFQ, but AS01B liposomes remained small nano-vesicles. Here, we show that saturation of phospholipid chains is essential for production of large liposomes by QS21.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Saponines
/
Cholestérol
/
Lipide A
/
Liposomes
Langue:
En
Journal:
J Liposome Res
Sujet du journal:
BIOQUIMICA
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique