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Involvement of caveolin-1 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis.
Blochet, Camille; Buscemi, Lara; Clément, Tifenn; Gehri, Sabrina; Badaut, Jérôme; Hirt, Lorenz.
Affiliation
  • Blochet C; Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland.
  • Buscemi L; Brain Molecular Imaging Lab, CNRS UMR 5287, INCIA, University of Bordeaux, Bordeaux, France.
  • Clément T; Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland.
  • Gehri S; Brain Molecular Imaging Lab, CNRS UMR 5287, INCIA, University of Bordeaux, Bordeaux, France.
  • Badaut J; Department of Clinical Neurosciences, CHUV, Lausanne, Switzerland.
  • Hirt L; Brain Molecular Imaging Lab, CNRS UMR 5287, INCIA, University of Bordeaux, Bordeaux, France.
J Cereb Blood Flow Metab ; 40(1): 163-176, 2020 01.
Article de En | MEDLINE | ID: mdl-30354902
ABSTRACT
Complex cellular and molecular events occur in the neurovascular unit after stroke, such as blood-brain barrier (BBB) dysfunction and inflammation that contribute to neuronal death, neurological deterioration and mortality. Caveolin-1 (Cav-1) has distinct physiological functions such as caveolae formation associated with endocytosis and transcytosis as well as in signaling pathways. Cav-1 has been proposed to be involved in BBB dysfunction after brain injury; however, its precise role is poorly understood. The goal of this study was to characterize the expression and effect of Cav-1 deletion on outcome in the first week in a transient Middle Cerebral Artery Occlusion stroke model. We found increased Cav-1 expression in new blood vessels in the lesion and in reactive astrocytes in the peri-lesion areas. In Cav-1 KO mice, the lesion volume was larger and the behavioral outcome worse than in WT mice. Cav-1 KO mice exhibited reduced neovascularization and modified astrogliosis, without formation of a proper glial scar around the lesion at three days post injury, coinciding with aggravated outcomes. Altogether, these results point towards a potential protective role of endogenous Cav-1 in the first days after ischemia by promoting neovascularization, astrogliosis and scar formation.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Accident vasculaire cérébral / Cavéoline-1 / Néovascularisation pathologique / Plasticité neuronale Type d'étude: Etiology_studies Limites: Animals Langue: En Journal: J Cereb Blood Flow Metab Année: 2020 Type de document: Article Pays d'affiliation: Suisse

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Accident vasculaire cérébral / Cavéoline-1 / Néovascularisation pathologique / Plasticité neuronale Type d'étude: Etiology_studies Limites: Animals Langue: En Journal: J Cereb Blood Flow Metab Année: 2020 Type de document: Article Pays d'affiliation: Suisse