Impact of Replication Stress in Human Papillomavirus Pathogenesis.
J Virol
; 93(2)2019 01 15.
Article
de En
| MEDLINE
| ID: mdl-30355682
ABSTRACT
The inactivation of critical cell cycle checkpoints by the human papillomavirus (HPV) oncoprotein E7 results in replication stress (RS) that leads to genomic instability in premalignant lesions. Intriguingly, RS tolerance is achieved through several mechanisms, enabling HPV to exploit the cellular RS response for viral replication and to facilitate viral persistence in the presence of DNA damage. As such, inhibitors of the RS response pathway may provide a novel approach to target HPV-associated lesions and cancers.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Papillomaviridae
/
Infections à papillomavirus
/
Instabilité du génome
/
Protéines E7 de papillomavirus
Type d'étude:
Etiology_studies
Limites:
Humans
Langue:
En
Journal:
J Virol
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique