Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes.
Curr Opin Microbiol
; 46: 109-115, 2018 12.
Article
de En
| MEDLINE
| ID: mdl-30366310
ABSTRACT
Plasmodium vivax is uniquely restricted to invading reticulocytes, the youngest of red blood cells. Parasite invasion relies on the sequential deployment of multiple parasite invasion ligands. Correct targeting of the host reticulocyte is mediated by two families of invasion ligands the reticulocyte binding proteins (RBPs) and erythrocyte binding proteins (EBPs). The Duffy receptor has long been established as a key determinant for P. vivax invasion. However, recently, the RBP protein PvRBP2b has been shown to bind to transferrin receptor, which is expressed on reticulocytes but lost on normocytes, implicating the ligand-receptor in the reticulocyte tropism of P. vivax. Furthermore there is increasing evidence for P. vivax growth and sexual development in reticulocyte-enriched tissues such as the bone marrow.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plasmodium vivax
/
Réticulocytes
/
Paludisme à Plasmodium vivax
Limites:
Animals
/
Humans
Langue:
En
Journal:
Curr Opin Microbiol
Sujet du journal:
MICROBIOLOGIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique