UTE-SENCEFUL: first results for 3D high-resolution lung ventilation imaging.
Magn Reson Med
; 81(4): 2464-2473, 2019 04.
Article
de En
| MEDLINE
| ID: mdl-30393947
ABSTRACT
PURPOSE:
This study aimed to develop a 3D MRI technique to assess lung ventilation in free-breathing and without the administration of contrast agent.METHODS:
A 3D-UTE sequence with a koosh ball trajectory was developed for a 3 Tesla scanner. An oversampled k-space was acquired, and the direct current signal from the k-space center was used as a navigator to sort the acquired data into 8 individual breathing phases. Gradient delays were corrected, and iterative SENSE was used to reconstruct the individual timeframes. Subsequently, the signal changes caused by motion were eliminated using a 3D image registration technique, and ventilation-weighted maps were created by analyzing the signal changes in the lung tissue. Six healthy volunteers and 1 patient with lung cancer were scanned with the new 3D-UTE and the standard 2D technique. Image quality and quantitative ventilation values were compared between both methods.RESULTS:
UTE-based self-gated noncontrast-enhanced functional lung (SENCEFUL) MRI provided a time-resolved reconstruction of the breathing motion, with a 49% increase of the SNR. Ventilation quantification for healthy subjects was in statistical agreement with 2D-SENCEFUL and the literature, with a mean value of 0.11 ± 0.08 mL/mL for the whole lung. UTE-SENCEFUL was able to visualize and quantify ventilation deficits in a patient with lung tumor that were not properly depicted by 2D-SENCEFUL.CONCLUSION:
UTE-SENCEFUL represents a robust MRI method to assess both morphological and functional information of the lungs in 3D. When compared to the 2D approach, 3D-UTE offered ventilation maps with higher resolution, improved SNR, and reduced ventilation artifacts.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Respiration
/
Traitement d'image par ordinateur
/
Produits de contraste
/
Imagerie tridimensionnelle
/
Poumon
/
Tumeurs du poumon
Limites:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Magn Reson Med
Sujet du journal:
DIAGNOSTICO POR IMAGEM
Année:
2019
Type de document:
Article
Pays d'affiliation:
Allemagne