As time flies by: Investigating cardiac aging in the short-lived Drosophila model.
Biochim Biophys Acta Mol Basis Dis
; 1865(7): 1831-1844, 2019 07 01.
Article
de En
| MEDLINE
| ID: mdl-30496794
ABSTRACT
Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vieillissement
/
Drosophila melanogaster
/
Coeur
Limites:
Animals
/
Humans
Langue:
En
Journal:
Biochim Biophys Acta Mol Basis Dis
Année:
2019
Type de document:
Article