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Visual detection of cancer cells by using in situ grown functional Cu2-xSe/reduced graphene oxide hybrids acting as an efficient nanozyme.
Guo, Qing Juan; Pan, Zi Yu; Men, Chen; Lv, Wen Yi; Zou, Hong Yan; Huang, Cheng Zhi.
Affiliation
  • Guo QJ; Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, P. R. China. zhy2013@swu.edu.cn.
  • Pan ZY; Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, P. R. China. zhy2013@swu.edu.cn.
  • Men C; College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, P. R. China. chengzhi@swu.edu.cn.
  • Lv WY; Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, P. R. China. zhy2013@swu.edu.cn.
  • Zou HY; Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, P. R. China. zhy2013@swu.edu.cn.
  • Huang CZ; Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, P. R. China. zhy2013@swu.edu.cn and College of Chemistry and Chemical Engineering, Southwest University, Chong
Analyst ; 144(2): 716-721, 2019 Jan 21.
Article de En | MEDLINE | ID: mdl-30520465
ABSTRACT
A simple protocol for in situ growth of Cu2-xSe nanoparticles on graphene oxide hybrids (Cu2-xSe/rGO) acting as an efficient nanozyme is developed and thus a sensitive visual detection method of cancer cells is proposed. The Cu2-xSe/rGO heterogeneous nanomaterials have been proven to exhibit high peroxidase-like activity to catalyze the reaction of the peroxidase substrate in the presence of hydrogen peroxide. Herein, we used Cu2-xSe/rGO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells and a total of 63 cancer cells (MCF-7) can be distinguished by naked-eye observation. The results showed that the Cu2-xSe/rGO hybrids could be the promising nanozyme mimetics for potential applications in bioanalytical fields.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Oxydes / Sélénium / Colorimétrie / Cuivre / Matériaux biomimétiques / Nanostructures / Graphite Type d'étude: Diagnostic_studies Limites: Humans Langue: En Journal: Analyst Année: 2019 Type de document: Article

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Oxydes / Sélénium / Colorimétrie / Cuivre / Matériaux biomimétiques / Nanostructures / Graphite Type d'étude: Diagnostic_studies Limites: Humans Langue: En Journal: Analyst Année: 2019 Type de document: Article