Mechanically magnified chitosan-based hydrogel as tissue adhesive and antimicrobial candidate.
Int J Biol Macromol
; 125: 109-115, 2019 Mar 15.
Article
de En
| MEDLINE
| ID: mdl-30521916
ABSTRACT
The present article reports the development of chitosan (CS) based hydrogel series by varying the concentration of cross-linking agent i.e. N,N'-methylenebisacrylamide (MBA) (0.8-1.4â¯wt%) via free-radical polymerization in aqueous medium. SEM image analysis confirmed the presence of porous 3D-network in the hydrogel. Prepared hydrogel series exhibited good tissue adhesive property along with antimicrobial activity against E. coli, K. pneumonia, S. aureus, C. albicans &M. gypseum bacteria with the good MIC (4-20â¯mm). The adhesive strength of hydrogel was found 14â¯kPa, which seems to be quite efficient in tissue adhesiveness applications, which was also validated and tested on Drosophila (Oregon-R) tissues, results were promising. Magnified mechanical strength i.e. storage modulus (G') and loss modulus (Gâ³) were found 106â¯Pa and 104â¯Pa, respectively, which makes the hydrogel a potential candidate in the biomedical field. Moreover, CS hydrogel showed good swelling ratio in aqueous medium up to 390% at room temperature.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Adhésifs tissulaires
/
Hydrogels
/
Chitosane
/
Anti-infectieux
Langue:
En
Journal:
Int J Biol Macromol
Année:
2019
Type de document:
Article
Pays d'affiliation:
Inde