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Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.
Kumar, Malkeet; Okombo, John; Mambwe, Dickson; Taylor, Dale; Lawrence, Nina; Reader, Janette; van der Watt, Mariëtte; Fontinha, Diana; Sanches-Vaz, Margarida; Bezuidenhout, Belinda C; Lauterbach, Sonja B; Liebenberg, Dale; Birkholtz, Lyn-Marie; Coetzer, Theresa L; Prudêncio, Miguel; Egan, Timothy J; Wittlin, Sergio; Chibale, Kelly.
Affiliation
  • Kumar M; Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Okombo J; Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Mambwe D; Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Taylor D; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory 7925 , South Africa.
  • Lawrence N; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory 7925 , South Africa.
  • Reader J; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control , University of Pretoria , Private Bag X20 , Hatfield 0028 , South Africa.
  • van der Watt M; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control , University of Pretoria , Private Bag X20 , Hatfield 0028 , South Africa.
  • Fontinha D; Instituto de Medicina Molecular, Faculdade de Medicina , Universidade de Lisboa , Av. Prof. Egas Moniz , 1649-028 Lisboa , Portugal.
  • Sanches-Vaz M; Instituto de Medicina Molecular, Faculdade de Medicina , Universidade de Lisboa , Av. Prof. Egas Moniz , 1649-028 Lisboa , Portugal.
  • Bezuidenhout BC; Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences , University of the Witwatersrand and National Health Laboratory Service , Johannesburg 2193 , South Africa.
  • Lauterbach SB; Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences , University of the Witwatersrand and National Health Laboratory Service , Johannesburg 2193 , South Africa.
  • Liebenberg D; Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences , University of the Witwatersrand and National Health Laboratory Service , Johannesburg 2193 , South Africa.
  • Birkholtz LM; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control , University of Pretoria , Private Bag X20 , Hatfield 0028 , South Africa.
  • Coetzer TL; Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences , University of the Witwatersrand and National Health Laboratory Service , Johannesburg 2193 , South Africa.
  • Prudêncio M; Instituto de Medicina Molecular, Faculdade de Medicina , Universidade de Lisboa , Av. Prof. Egas Moniz , 1649-028 Lisboa , Portugal.
  • Egan TJ; Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Wittlin S; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch 7701 , South Africa.
  • Chibale K; Swiss Tropical and Public Health Institute , Socinstrasse 57 , 4002 Basel , Switzerland.
ACS Infect Dis ; 5(2): 303-315, 2019 02 08.
Article de En | MEDLINE | ID: mdl-30525439
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Plasmodium falciparum / Astémizole / Hémoprotéines / Antipaludiques Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: ACS Infect Dis Année: 2019 Type de document: Article Pays d'affiliation: République d'Afrique du Sud Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Plasmodium falciparum / Astémizole / Hémoprotéines / Antipaludiques Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: ACS Infect Dis Année: 2019 Type de document: Article Pays d'affiliation: République d'Afrique du Sud Pays de publication: États-Unis d'Amérique