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Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Tron, Adriana E; Belmonte, Matthew A; Adam, Ammar; Aquila, Brian M; Boise, Lawrence H; Chiarparin, Elisabetta; Cidado, Justin; Embrey, Kevin J; Gangl, Eric; Gibbons, Francis D; Gregory, Gareth P; Hargreaves, David; Hendricks, J Adam; Johannes, Jeffrey W; Johnstone, Ricky W; Kazmirski, Steven L; Kettle, Jason G; Lamb, Michelle L; Matulis, Shannon M; Nooka, Ajay K; Packer, Martin J; Peng, Bo; Rawlins, Philip B; Robbins, Daniel W; Schuller, Alwin G; Su, Nancy; Yang, Wenzhan; Ye, Qing; Zheng, Xiaolan; Secrist, J Paul; Clark, Edwin A; Wilson, David M; Fawell, Stephen E; Hird, Alexander W.
Affiliation
  • Tron AE; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Belmonte MA; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Adam A; LifeMine Therapeutics, Cambridge, MA, USA.
  • Aquila BM; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Boise LH; Surface Oncology, Cambridge, MA, USA.
  • Chiarparin E; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Cidado J; Alkermes, Inc., Waltham, MA, USA.
  • Embrey KJ; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Gangl E; Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA.
  • Gibbons FD; Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Gregory GP; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Hargreaves D; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Hendricks JA; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Johannes JW; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Johnstone RW; School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3800, Australia.
  • Kazmirski SL; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
  • Kettle JG; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Lamb ML; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Matulis SM; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Nooka AK; Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
  • Packer MJ; The Sir Peter MacCallum Center, Department of Oncology, University of Melbourne, Parkville, VIC, 3000, Australia.
  • Peng B; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Rawlins PB; Fulcrum Therapeutics, Cambridge, MA, USA.
  • Robbins DW; Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Schuller AG; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Su N; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Yang W; Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA.
  • Ye Q; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Zheng X; Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA.
  • Secrist JP; Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, SK10 4TG, UK.
  • Clark EA; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Wilson DM; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK.
  • Fawell SE; Oncology, IMED Biotech Unit, AstraZeneca, Waltham, MA, 02451, USA.
  • Hird AW; Nurix, Inc., San Francisco, CA, USA.
Nat Commun ; 9(1): 5341, 2018 12 17.
Article de En | MEDLINE | ID: mdl-30559424
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Leucémie aigüe myéloïde / Apoptose / Protéine Mcl-1 / Myélome multiple / Antinéoplasiques Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2018 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Leucémie aigüe myéloïde / Apoptose / Protéine Mcl-1 / Myélome multiple / Antinéoplasiques Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2018 Type de document: Article Pays d'affiliation: États-Unis d'Amérique