Curcumanes A and B, Two Bicyclic Sesquiterpenoids with Significant Vasorelaxant Activity from Curcuma longa.
Org Lett
; 21(4): 1197-1201, 2019 02 15.
Article
de En
| MEDLINE
| ID: mdl-30702896
ABSTRACT
Two novel sesquiterpenoids, curcumanes A (1) and B (2), possessing unprecedented skeletons with a dicyclo[3.2.1]octane and a dicyclo[3.3.1]nonane moiety, respectively, were isolated from Curcuma longa. Both of them had remarkable vasorelaxant activity on rat aorta via blocking extracellular Ca2+ influx through VDCCs and ROCCs. The activity of 1 was endothelium-independent, while that of 2 was endothelium-dependent. Compound 2 also prolonged APTT and TT to inhibit blood coagulation.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Aorte thoracique
/
Vasodilatateurs
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Inhibiteurs des canaux calciques
/
Canaux calciques
/
Curcuma
/
Récepteurs-détecteurs du calcium
/
Sesquiterpènes polycycliques
Limites:
Animals
Langue:
En
Journal:
Org Lett
Sujet du journal:
BIOQUIMICA
Année:
2019
Type de document:
Article