Early-life sleep disruption increases parvalbumin in primary somatosensory cortex and impairs social bonding in prairie voles.
Sci Adv
; 5(1): eaav5188, 2019 01.
Article
de En
| MEDLINE
| ID: mdl-30729165
ABSTRACT
Across mammals, juveniles sleep more than adults, with rapid eye movement (REM) sleep at a lifetime maximum early in life. One function of REM sleep may be to facilitate brain development of complex behaviors. Here, we applied 1 week of early-life sleep disruption (ELSD) in prairie voles (Microtus ochrogaster), a highly social rodent species that forms lifelong pair bonds. Electroencephalographic recordings from juvenile voles during ELSD revealed decreased REM sleep and reduced γ power compared to baseline. ELSD impaired pair bond formation and altered object preference in adulthood. Furthermore, ELSD increased GABAergic parvalbumin immunoreactivity in the primary somatosensory cortex in adulthood, a brain region relevant to both affected behaviors. We propose that, early in life, sleep is crucial for tuning inhibitory neural circuits and the development of species-typical affiliative social behavior.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Monogamie
/
Parvalbumines
/
Privation de sommeil
/
Comportement social
/
Cortex somatosensoriel
/
Arvicolinae
Aspects:
Determinantes_sociais_saude
Limites:
Animals
Langue:
En
Journal:
Sci Adv
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique