Abiraterone acetate to treat metastatic castration-resistant prostate cancer in combination with prednisone.
Drugs Today (Barc)
; 55(1): 5-15, 2019 01.
Article
de En
| MEDLINE
| ID: mdl-30740608
ABSTRACT
Prostate cancer is one of the most common cancers in the United States, with an estimated incidence of 164,690 cases, accounting for 9.5% of all new cancer diagnoses. The mainstay of therapy for metastatic prostate cancer involves suppressing testosterone production through androgen deprivation therapy. However, nearly all patients on androgen deprivation therapy will develop resistance to hormone therapy. An improved understanding of the biology of castration resistance has allowed for the development of novel inhibitors of the androgen axis. Agents such as abiraterone acetate, which provides additional androgen suppression by inhibiting cytochrome P450 17A (CYP17A), have improved survival outcomes of patients with advanced prostate cancer. The longest experience with abiraterone acetate is in the metastatic castration-resistant setting. However, more recent trials have demonstrated that abiraterone acetate is an option for treatment earlier in the prostate cancer paradigm. This review will cover the current use of abiraterone acetate in combination with prednisone for the treatment of castration-resistant prostate cancer.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Prednisone
/
Tumeurs prostatiques résistantes à la castration
/
Acétate d'abiratérone
/
Antagonistes des androgènes
Limites:
Humans
/
Male
Langue:
En
Journal:
Drugs Today (Barc)
Sujet du journal:
MEDICINA OCUPACIONAL
/
SAUDE AMBIENTAL
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique