5-HT3A serotonin receptor in the gastrointestinal tract: the link between immune system and enteric nervous system in the digestive form of Chagas disease.
Parasitol Res
; 118(4): 1325-1329, 2019 Apr.
Article
de En
| MEDLINE
| ID: mdl-30747295
ABSTRACT
Chagas disease is caused by Trypanosoma cruzi and remains one of the most neglected diseases in Latin America. One of its clinical forms is Chagas megacolon. Despite being known for more than half a century, detailed causes are still obscure. Recent evidence indicates a close relationship between the immune system and the enteric nervous system in the etiology of chagasic megacolon pathology. It is believed that low expression of the 5-HT3A serotonin receptor on lymphocytes could be linked to megacolon development. To test this hypothesis, this work investigated the distribution of CD4, CD8, and CD20 lymphocytes and their 5-HT3A receptor expression. The results demonstrated that Chagas patients without megacolon present a higher expression of the 5-HT3A receptor in all analyzed lymphocytes compared with Chagas patients with megacolon. These data suggest that the high expression of this receptor may lead to immunomodulation and prevent the development of Chagas megacolon.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladie de Chagas
/
Système nerveux entérique
/
Récepteurs sérotoninergiques 5-HT3
/
Système immunitaire
/
Mégacôlon
Limites:
Humans
/
Middle aged
Langue:
En
Journal:
Parasitol Res
Sujet du journal:
PARASITOLOGIA
Année:
2019
Type de document:
Article
Pays d'affiliation:
Brésil