Eukaryotic initiation factor 4A (eIF4A) during viral infections.
Virus Genes
; 55(3): 267-273, 2019 Jun.
Article
de En
| MEDLINE
| ID: mdl-30796742
ABSTRACT
The helicase eIF4A is part of the cellular eIF4F translation initiation complex. The main functions of eIF4A are to remove secondary complex structures within the 5'-untranslated region and to displace proteins attached to mRNA. As intracellular parasites, viruses regulate the processes involved in protein synthesis, and different mechanisms related to controlling translation factors, such as eIF4A, have been found. The inhibitors of this factor are currently known; these substances could be used in the near future as part of antiviral pharmacological therapies in instances of replication cycles in which eIF4A is required. In this review, the particularities of how some viruses make use of this initiation factor to synthesize their proteins are discussed.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Biosynthèse des protéines
/
Maladies virales
/
Facteur-4A d'initiation eucaryote
Limites:
Humans
Langue:
En
Journal:
Virus Genes
Sujet du journal:
BIOLOGIA MOLECULAR
/
VIROLOGIA
Année:
2019
Type de document:
Article
Pays d'affiliation:
Mexique