Separating extracellular vesicles and lipoproteins via acoustofluidics.
Lab Chip
; 19(7): 1174-1182, 2019 03 27.
Article
de En
| MEDLINE
| ID: mdl-30806400
ABSTRACT
Extracellular vesicles (EVs) and lipoproteins are abundant and co-exist in blood. Both have been proven to be valuable as diagnostic biomarkers and for therapeutics. However, EVs and lipoproteins are both on the submicron scale and overlap in size distributions. Conventional methods to separate EVs and lipoproteins are inefficient and time-consuming. Here we present an acoustofluidic-based separation technique that is based on the acoustic property differences of EVs and lipoproteins. By using the acoustofluidic technology, EVs and subgroups of lipoproteins are separated in a label-free, contact-free, and continuous manner. With its ability for simple, rapid, efficient, continuous-flow isolation, our acoustofluidic technology could be a valuable tool for health monitoring, disease diagnosis, and personalized medicine.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Acoustique
/
Laboratoires sur puces
/
Vésicules extracellulaires
/
Lipoprotéines
Limites:
Humans
Langue:
En
Journal:
Lab Chip
Sujet du journal:
BIOTECNOLOGIA
/
QUIMICA
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique